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Table 3 Functional specialization of HSN zones defined by distance from the network centre

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Enriched Pathway

Zone 1

Zone 2

Zone 3

Zone 4

Signal transduction

40.6%

21.1%

9.3%

16%

Immune system

33.6%

16.2%

8.4%

-

MAPK signalling

28.9%

3.5%

-

-

Pathways in cancer

21.4%

5.7%

-

-

Disease

21%

10%

7.2%

9.8%

Hemostasis

16.5%

6.9%

3.3%

-

Cell Cycle

5.3%

7.6%

3.4%

-

Gene expression

7.2%

7.5%

8.7%

-

Metabolism of proteins

-

4.6%

4.6%

-

  1. Percentages indicate proportion of proteins in a zone belonging to the specific functional class.