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Table 3 Functional specialization of HSN zones defined by distance from the network centre

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Enriched Pathway Zone 1 Zone 2 Zone 3 Zone 4
Signal transduction 40.6% 21.1% 9.3% 16%
Immune system 33.6% 16.2% 8.4% -
MAPK signalling 28.9% 3.5% - -
Pathways in cancer 21.4% 5.7% - -
Disease 21% 10% 7.2% 9.8%
Hemostasis 16.5% 6.9% 3.3% -
Cell Cycle 5.3% 7.6% 3.4% -
Gene expression 7.2% 7.5% 8.7% -
Metabolism of proteins - 4.6% 4.6% -
  1. Percentages indicate proportion of proteins in a zone belonging to the specific functional class.