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Table 6 Distribution of essential, drug target and classical cancer proteins in HSN zones

From: Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery

Zone

Essential

Drug

Oncogenes

Tumour

 

roles

targets

 

suppressors

1

157 (36.4%)

69 (16%)

12 (2.7%)

12 (2.7%)

2

815 (23.1%)

291 (8.2%)

33 (0.9%)

41 (1.1%)

3

268 (13.8%)

103 (5.3%)

4 (0.02%)

4 (0.2%)

4

29 (14%)

5 (2.4%)

-

-

5

4 (10.5%)

1 (2.6%)

-

1 (2.6%)