Figure 7

Concentration effects on gene set (AUC%) analysis. Areas under each sensitivity vs. rank threshold curve (ROC curve) for FL-interacters and orthogonal gene sets were converted to percentages (AUC%s) and plotted for each FL microarray concentration experiment. Cells were treated with FL concentrations that corresponded to increasing growth inhibitory percentages, GI%s (x-axis). Mean AUC%s (GI_0.5 to GI₄₀) for each gene set were computed and compared in the table. Larger AUC% values indicated better prediction of FL action on a gene set. AUC% values were the averages of two replicates.