Figure 11

The binding of PLC γ 1 to EGFR. (a) Two states “bndPLCg992” and “bndPLCg1173”, represented as red and blue squares, have to be “off” for PLC γ 1 to be able to bind to site pY992. (b) All three states “bndPLCg992”, “bndPLCg1173” and “bndSHC1148”, represented as red, blue and green squares, have to be “off” for PLC γ 1 to be able to bind to site pY1173.