Figure 7
From: Metabolomics of Apc Min/+ mice genetically susceptible to intestinal cancer
Proposed biological model involving hippuric acid metabolism. This model derives from the most significant IPA metabolic interaction network plotted in Figure 4 in relation to the plasma metabolites correlated with polyp counts and associated with a Genotype by Diet interaction (listed in Table 3 and Additional file 9: Table S5). The sketch displays the workflow of benzoic acid (benzoate - Bz) uptake by intestinal polyps, followed by its transport to the liver, its reaction with glycine (Gly) to produce hippuric acid (hippurate) and its final release in the plasma.