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Table 3 Reactome pathways with significant representation of kinases from the regression analysis

From: Prediction of kinase inhibitor response using activity profiling, in vitro screening, and elastic net regression

Path ID Path name NS NT p-val
422475 Axon guidance 9 31 0.005
428540 Activation of Rac 3 5 0.008
373755 Semaphorin interactions 4 10 0.011
376176 Signaling by Robo receptor 3 7 0.024
1266738 Developmental Biology 8 39 0.026
445144 Signal transduction by L1 4 13 0.030
373760 L1CAM interactions 4 14 0.040
193639 p75NTR signals via NF-kB 2 4 0.051
209543 p75NTR recruits signaling complexes 2 4 0.051
389359 CD28 dependent Vav1 pathway 2 4 0.051
  1. Ns indicates the number of kinases that are found significant in the regression analysis, while NT is the total number of kinases in the pathway. The top ten pathways with Fisher exact test p < =0.051 are shown. These pathways are identified from 518. Reactome pathways containing at least one of the kinases identified in Table 2. The 9 kinases in the axon-guidance pathway are EGFR, PAK1, ERBB2, CDK5, GSK3B, PAK2, RPS6KA2, FGFR1 and PAK7.