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Table 3 Reactome pathways with significant representation of kinases from the regression analysis

From: Prediction of kinase inhibitor response using activity profiling, in vitro screening, and elastic net regression

Path ID

Path name

NS

NT

p-val

422475

Axon guidance

9

31

0.005

428540

Activation of Rac

3

5

0.008

373755

Semaphorin interactions

4

10

0.011

376176

Signaling by Robo receptor

3

7

0.024

1266738

Developmental Biology

8

39

0.026

445144

Signal transduction by L1

4

13

0.030

373760

L1CAM interactions

4

14

0.040

193639

p75NTR signals via NF-kB

2

4

0.051

209543

p75NTR recruits signaling complexes

2

4

0.051

389359

CD28 dependent Vav1 pathway

2

4

0.051

  1. Ns indicates the number of kinases that are found significant in the regression analysis, while NT is the total number of kinases in the pathway. The top ten pathways with Fisher exact test p < =0.051 are shown. These pathways are identified from 518. Reactome pathways containing at least one of the kinases identified in Table 2. The 9 kinases in the axon-guidance pathway are EGFR, PAK1, ERBB2, CDK5, GSK3B, PAK2, RPS6KA2, FGFR1 and PAK7.