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Figure 1 | BMC Systems Biology

Figure 1

From: Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines

Figure 1

Modelling workflow. The figure summarises the applied modelling approach. RPPA data of three individual breast cancer cell lines were generated under short- and long-term drug treatment. They constituted the basis for network reconstruction in combination with prior literature knowledge about protein wiring. The reconstructed networks per cell line and time course in turn underwent Boolean perturbation simulations to reveal optimal drug treatments.

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BMC Systems Biology

ISSN: 1752-0509

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