Figure 1From: Systems biology modeling of omics data: effect of cyclosporine a on the Nrf2 pathway in human renal cells Schematic representation of the calibration (1) and prediction (2) processes used in this article. The coupled pharmacokinetic-systems biology model (PKSB) of the Nrf2 pathway was calibrated by MCMC sampling in a Bayesian framework with PK and omics data obtained during repeated treatment of RPTECs by CsA. After calibration, the model was used to make predictions enabling model checking.Back to article page