Skip to main content

Table 1 In vitro CsA kinetic parameters description and their statistical distributions

From: Systems biology modeling of omics data: effect of cyclosporine a on the Nrf2 pathway in human renal cells

Parameter

Description

Units

Prior

Posterior mode, mean ± SD

C L i n 1

Diffusion rate constant for cellular uptake

μm3.sec−1

LU*(10−1, 104)

99.6,

99.8 ± 21

K m ou t 1

Michaelis constant for diffusion for cellular efflux

μmol.L−1

LU (100, 50000)

2965,

3160 ± 620

C L ou t 1 K m ou t 1

Diffusion rate constant over Michaelis constant for cellular efflux

μm3.sec−1

LU (10−2, 20)

0.581,

0.568 ± 0.16

k 1

Plastic binding rate constant

sec−1

LU (10−6, 5 × 10−4)

3.55 × 10−5,

3.54 × 10−5 ± 1.0 × 10−5

k 3

Power law coefficient for unbinding

dimensionless

Uniform (0, 0.95)

0.921,

0.802 ± 0.074

k 2

Plastic unbinding rate constant

zmol(1-k3)**.sec−1

LU (10−4, 0.5)

6.01 × 10−4,

6.09 × 10−3 ± 8.7 × 10−3

v max

Maximum rate of metabolism

zmol.sec−1

LU (0.1, 5000)

40.0,

47.2 ± 14

K m 2

Michaelis constant for intra-cellular metabolism

zmol

LU (5 × 105, 5 × 107)

2.18 × 106,

3.43 × 106 ± 2.2 × 106

  1. *: LU: Log-uniform distribution (lower bound, upper bound).
  2. **: 1 zmol = 1 zeptomole = 10−21 mol.