Parameter | Description | Units | Prior | Posterior mode, mean ± SD |
---|---|---|---|---|
| Diffusion rate constant for cellular uptake | μm3.sec−1 | LU*(10−1, 104) | 99.6, |
99.8 ± 21 | ||||
| Michaelis constant for diffusion for cellular efflux | μmol.L−1 | LU (100, 50000) | 2965, |
3160 ± 620 | ||||
| Diffusion rate constant over Michaelis constant for cellular efflux | μm3.sec−1 | LU (10−2, 20) | 0.581, |
0.568 ± 0.16 | ||||
k 1 | Plastic binding rate constant | sec−1 | LU (10−6, 5 × 10−4) | 3.55 × 10−5, |
3.54 × 10−5 ± 1.0 × 10−5 | ||||
k 3 | Power law coefficient for unbinding | dimensionless | Uniform (0, 0.95) | 0.921, |
0.802 ± 0.074 | ||||
k 2 | Plastic unbinding rate constant | zmol(1-k3)**.sec−1 | LU (10−4, 0.5) | 6.01 × 10−4, |
6.09 × 10−3 ± 8.7 × 10−3 | ||||
v max | Maximum rate of metabolism | zmol.sec−1 | LU (0.1, 5000) | 40.0, |
47.2 ± 14 | ||||
| Michaelis constant for intra-cellular metabolism | zmol | LU (5 × 105, 5 × 107) | 2.18 × 106, |
3.43 × 106 ± 2.2 × 106 |