Parameter | Description | Units | Prior distribution | Posterior mode, mean ± SD |
---|---|---|---|---|
| Maximum rate of CsA metabolism | sec−1 | LN (0.2, 3) | 0.187 |
0.274 ± 0.233 | ||||
| Basal rate of ROS formation | zmol.sec−1 | LN (12, 3) | 79.1 |
135 ± 80.8 | ||||
| Maximum rate of ROS metabolism | sec−1 | LN (8, 3) | 2.67 |
3.88 ± 2.54 | ||||
| Keap1 oxidation rate constant | zmol−1.sec−1 | Uniform (10−8, 10−2) | 3.02 × 10−6 |
3.86 × 10−6 ± 2.72 × 10−6 | ||||
k ROS | ROS formation rate constant | sec−1 | Uniform (10−8, 10−2) | 6.55 × 10−5 |
8.86 × 10−6 ± 3.86 × 10−5 | ||||
| Nrf2 and Maf binding rate constant | sec−1 | LN (0.003, 3) | 0.0124 |
0.0193 ± 0.0167 | ||||
| mRNACYP transcription rate constant | sec−1 | LN (1.07, 3) | 1.29 |
1.65 ± 1.85 | ||||
| mRNANrf2 transcription rate constant | sec−1 | LN (0.00611, 3) | 0.087 |
0.062 ± 0.0603 | ||||
| mRNAGS transcription rate constant | sec−1 | LN (1.15, 3) | 1.07 |
1.34 ± 0.53 | ||||
| mRNAGCLC transcription rate constant | sec−1 | LN (1.98, 3) | 1.28 |
2.27 ± 1.91 | ||||
| mRNAGCLM transcription rateconstant | sec−1 | LN (3.22, 3) | 3.95 |
4.84 ± 3.79 | ||||
| mRNAGST transcription rate constant | sec−1 | LN (0.242, 3) | 0.021 |
0.553 ± 0.949 | ||||
| mRNAGPx transcription rate constant | sec−1 | LN (0.242, 3) | 0.098 |
0.123 ± 0.0779 | ||||
| mRNAMRP transcription rate constant | sec−1 | LN (0.9, 3) | 1.22 |
2.23 ± 3.55 | ||||
| GCLC and GCLM binding rate constant | sec−1 | LN (2 × 10−5, 3) | 4.33 × 10−6 |
1.09 × 10−5 ± 9.19 × 10−6 | ||||
| Induction coefficient for Nrf2 gene | zmol−1.sec−1 | LN (100, 3) | 150 |
236 ± 433 | ||||
| Induction coefficient for GS gene | zmol−1.sec−1 | LN (5.95, 3) | 2.17 |
3.85 ± 2.33 | ||||
| Induction coefficient for GCLC gene | zmol−1.sec−1 | LN (8.7, 3) | 22.1 |
43.2 ± 25 | ||||
| Induction coefficient for GCLM gene | zmol−1.sec−1 | LN (1.6, 3) | 3.28 |
5.75 ± 3.15 | ||||
| Induction coefficient for GST gene | zmol−1.sec−1 | LN (11.9, 3) | 8.46 |
10.4 ± 8.61 | ||||
| Induction coefficient for GPx gene | zmol−1.sec−1 | LN (11.9, 3) | 1.37 |
6.75 ± 6.51 | ||||
| Induction coefficient for MRP gene | zmol−1.sec−1 | LN (16, 3) | 6.43 |
9.62 ± 7.85 | ||||
| Maximum rate of γ-GC synthesis by GCL | sec−1 | LN (8.2, 3) | 83.4 |
80.3 ± 67.5 | ||||
| Maximum rate of γ-GC synthesis by GCLC | sec−1 | LN (1.9, 3) | 1.64 |
2.16 ± 3.11 | ||||
| Maximum rate of GSH synthesis | sec−1 | LN (6.5, 3) | 8.57 |
10.3 ± 4.43 | ||||
| Maximum rate of GSH degradation | zmol.sec−1 | LN (1845, 3) | 283 |
374 ± 353 | ||||
Km 74 | Michaelis-Menten constant of GSH degradation | zmol | LN (2 × 107, 3) | 1.62 × 108 |
2.22 × 108 ± 2.36 × 108 |