Table 16 Conflicts between EcoCyc–18.0–GEM growth predictions and experimental sulfur source utilization data for aerobic growth on Biolog PM plates at 37°C
From: A genome-scale metabolic flux model of Escherichia coli K–12 derived from the EcoCyc database
Phosphorus source | HT | Sim | Comments |
|---|---|---|---|
dTMP | + | – | dTMP, GMP, thymidine 3’-monophosphate, and thiophosphate are substrates of the periplasmic |
Thiophosphate | + | – | nonspecific phosphatases PhoA and AphA, and enzymatic reactions covering these metabolites will be added in the course of EcoCyc development. Other phosphorylated metabolites have not been associated with individual phosphatases, and their pathways of utilization are a subject of future research. |
3-phospho-D-glycerate | + | – | The route of phosphorus uptake from these sources is unknown. Although catabolic pathways |
2-phosphoglycolate | + | – | for these phosphorylated metabolites exist in EcoCyc, the route of phosphorus uptake may |
α-D-mannose 1-phosphate | + | – | involve nonspecific dephosphorylation. |
Glucosamine-6-phosphate | + | – | |
6-phospho-D-gluconate | + | – | |
O-phospho-D-tyrosine | + | – | |
O-phospho-D-serine | + | – | |
N-phospho-L-arginine | + | – | |
Trimetaphosphate | + | – | |
2-deoxy-D-glucose 6-phosphate | + | – | |
Creatine-phosphate | + | – | |
Dithiophosphate | + | – |