Figure 3
Modeling long-chain fatty acids oxidation (LCFA) in tricarboxylic acid (TCA) cycle. Introducing LCFA (C(16:0), C(18:0)) oxidation in the TCA cycle may be required to consistently model the response to several treatments, such as the (HB) dataset (Table 1). In this case, the model shown in Figure 2 is extended by introducing inputs of C(16:0) (R 141) and C(18:0) (R 142), and output of C(18:0) (R 143). C(16:0) oxidation (R 20) and C(18:0) oxidation (R 21) are modified accordingly.