| |
Dataset
|
Model name
|
Example of
|
Combinatorics of pathways
| |
Validation
|
Pathways with
|
|---|
| | | |
maximized
| | | | | | | |
nonrelevant flux
|
|---|
| | | |
function
|
R
19
|
R
15
|
R
14
|
R
8
|
R
64
|
R
63
|
R
13
|
values
|
|---|
| | | | |
NADPH
|
OAA →G3P
|
OAA →PYR
|
G3P →G6P
|
Peptide
|
Peptide
|
Pyr→ OAA
| |
|---|
| | | | |
oxidation
| | | |
hydrolysis
|
synthesis
| | |
|---|
|
Extreme flux distributions within the set of plausible solutions
|
(Ctrl)
|
B
|
v
15- v
19
|
0
|
1831
|
0
|
0
|
0
|
125
|
1835
|
R
13, R
64
|
|
(CN)
|
795
|
150
|
803
|
|
(Ctrl)
|
F
|
v
14- v
19
|
0
|
0
|
1831
|
0
|
0
|
125
|
1835
|
R
13, R
64
|
|
(CN)
|
795
|
150
|
803
|
|
(Ctrl)
|
D
|
v
8- v
19
|
0
|
0
|
0
|
3662
|
0
|
125
|
4
|
R
8, R
64
|
|
(CN)
|
1590
|
150
|
8
|
|
(Ctrl)
|
H
|
v
64- v
19
|
0
|
0
|
0
|
0
|
305
|
430
|
4
| |
|
(CN)
|
133
|
283
|
8
|
|
(Cntl)
|
A
|
v
15 + v
19
|
694
|
1714
|
0
|
0
|
0
|
125
|
1718
|
R
13, R
64
|
|
(CN)
|
22
|
791
|
150
|
799
|
|
(Ctrl)
|
E
|
v
14 + v
19
|
694
|
0
|
1714
|
0
|
0
|
125
|
1718
|
R
13, R
64
|
|
(CN)
|
22
|
791
|
150
|
799
|
|
(Ctrl)
|
C
|
v
8 + v
19
|
694
|
0
|
0
|
3428
|
0
|
125
|
4
|
R
8, R
64
|
|
(CN)
|
22
|
1583
|
150
|
8
|
|
(Ctrl)
|
G
|
v
64 + v
19
|
669
|
0
|
0
|
0
|
286
|
410
|
4
| |
| |
(CN)
|
22
|
132
|
282
|
8
|
|
Litterature-based upperbounds for fluxes
| | | | |
≤ 591
|
Non-zero
|
Lower than
|
≤ 266 mmol/h/half
| |
| | | | | | | |
mmol/
|
[28, 31]
|
whole body
|
udder [33]
| |
| | | | | | | |
h/half udder [33]
| |
protein synthesis [29]
| | |
- The qualitative properties of all vertices are shared in (Ctrl) and (CN) treatments. Both correspond to a simplex with height vertices. So are six of each of the (Ctrl) and (CN) simplex vertices. H and G vertices, in the (Ctrl) and (CN) treatments, are plausible with respect to the literature.
