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Table 6 Minimum and maximum utilization of input in each output

From: Exploring metabolism flexibility in complex organisms through quantitative study of precursor sets for system outputs

(Ctrl) treatment
Input Glucose Glycerol Acetate BHBA Lysine Threonine1 Isoleucine1 Leucine1 Valine1 Histidine1 Arginine1 Alanine1 Glutamine1
  1422 17,5 1020 336 16,1 1,40 13,1 12,1 12,7 1,38 26,4 9,33 6,10
Output Minimum and maximum utilisation of Input in each output (in mmol/h/half udder of Carbon)
   Min Max Min Max Min Max Min Max Min Max Min Max Min Max Min Max Min Max Min Max Min Max Min Max Min Max
Glycerol3P 98.9 32.9 97.0 1.24 12.5 0 38.4 0 16.0 0 1.1 0 0.1 0 1.3 0 1.0 0 1.2 0 0.1 0 2.0 0 1.0 0 0.6
Lactose 886 751 886 0 7.7 0 79.8 0 33.2 0 2.3 0 0.1 0 2.6 0 2.0 0 2.4 0 0.2 0 4.0 0 2.0 0 1.1
C4 40.3 0 0 0 40.3 0 0 0 0 0 0 0 0 0
c6 27.1 0 0 18.0 9.0 0 0 0 0 0 0 0 0 0
c8 17.8 0 0 13.4 4.5 0 0 0 0 0 0 0 0 0
c10 46.6 0 0 37.3 9.3 0 0 0 0 0 0 0 0 0
c12 50.8 0 0 42.3 8.5 0 0 0 0 0 0 0 0 0
c14 195 0 0 167 27.8 0 0 0 0 0 0 0 0 0
c16 301 0 0 263 37.6 0 0 0 0 0 0 0 0 0
Glycine 2 10.0 3.5 8.0 0.1 0.9 1.0 3.7 0.4 1.5 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.1 0.0 0.1
Glutamate 2 2.7 0.0 1.1 0.0 0.1 1.0 1.6 0.4 0.7 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1
Proline 2 53.3 0.7 20.8 0.0 0.7 20.0 32.4 8.3 13.5 0.5 0.7 0.0 0.1 0.4 0.9 0.5 0.8 0.3 0.7 0.0 0.1 1.0 1.8 0.2 0.6 0.3 0.5
Aspartate 2 13.7 0.2 7.4 0.0 0.3 3.8 8.2 1.6 3.4 0.1 0.2 0.0 0.1 0.1 0.3 0.1 0.2 0.1 0.3 0.0 0.1 0.2 0.4 0.0 0.2 0.0 0.1
Serine 2 21.6 7.0 20.6 0.3 2.6 0.0 8.2 0.0 3.4 0.0 0.2 0.4 0.4 0.0 0.3 0.0 0.2 0.0 0.3 0.2 0.3 0.0 0.4 0.0 0.2 0.0 0.1
CO2 1126 396 565 1.3 14.5 343 446 142 185 12.1 15.3 0.7 0.8 9.1 12.4 8.7 11.3 9.1 12.1 0.7 1.0 15.1 20.3 6.3 8.8 4.2 5.6
  1. A local-search algorithm allowed us to compute the minima and maxima of each AIO coefficient for the two treatments (Ctrl), (CN) (in mmol/h/half udder of Carbon). These tables allow discriminating the response of the mammary gland to the two treatments without requiring selection of a flux distribution for reactions in the metabolic network. (CN) treatment (protein intake by food) is characterized by a lower proportion of glucose which is oxidized in CO2 than in (Ctrl).
  2. (1)Amino acid input corresponded to positive balances between amino acid net uptake and amino acid and utilization in milk protein (i.e. peptide output).
  3. (2)Amino acid Output corresponded to negative balance between, amino acid net uptake and utilization in milk protein (i.e. peptide output).