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Table 7 Minimum and maximum utilization of input in each output

From: Exploring metabolism flexibility in complex organisms through quantitative study of precursor sets for system outputs

(CN) treatment
Input Glucose Glycerol Acetate BHBA Lysine1 Isoleucine1 Leucine1 Valine1 Arginine1 Glutamine1
   1392 17.2 924 668 21.5 21.4 22.6 19.3 26.9 8.95
Output Minimum and maximum utilisation of input in each output (in mmol/h/half udder of Carbon)
   Min Max Min Max Min Max Min Max Min Max Min Max Min Max Min Max Min Max Min Max
Glycerol3P 117 36.1 115 1.8 11.3 0 22.8 0 44.5 0 1.6 0 2.3 0.0 2.0 0.0 2.0 0.0 2.2 0.0 0.9
Lactose 1002 866 1002 0 9.2 0 37.9 0 74.0 0 2.6 0 3.9 0.0 3.3 0.0 3.3 0.0 3.7 0.0 1.5
C4 46.4 0 0 0 46.4 0 0 0 0 0 0
C6 33.5 0 0 22.3 11.2 0 0 0 0 0 0
C8 23.0 0 0 17.2 5.7 0 0 0 0 0 0
C10 64.6 0 0 51.7 12.9 0 0 0 0 0 0
C12 73.4 0 0 61.2 12.2 0 0 0 0 0 0
C14 250 0 0 215 35.8 0 0 0 0 0 0
C16 343 0 0 300 42.9 0 0 0 0 0 0
glycine 2 6.9 2.1 5.5 0.0 0.5 0.4 1.3 0.7 2.6 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.1
Alanine 2 9.8 1.4 9.6 0.0 0.9 0 2.4 0 4.7 0 0.2 0 0.3 0 0.2 0 0.2 0 0.2 0 0.1
glutamate 2 31.7 0.8 8.8 0.0 0.4 6.7 9.0 13.0 17.6 0.4 0.5 0.4 0.7 0.6 0.8 0.3 0.5 0.7 0.9 0.3 0.4
proline 2 55.0 1.4 15.3 0.0 0.6 11.6 15.6 22.6 30.5 0.7 0.9 0.8 1.3 1.0 1.4 0.5 0.9 1.2 1.6 0.5 0.7
aspartate 2 16.5 0.6 7.0 0.0 0.3 2.7 4.5 5.3 8.9 0.2 0.3 0.3 0.5 0.2 0.4 0.2 0.4 0.3 0.5 0.1 0.2
serine 2 22.5 6.9 22.0 0.3 2.2 0 4.4 0 8.5 0 0.3 0 0.4 0 0.4 0 0.4 0 0.4 0 0.2
CO2 1021 244 402 2.0 12.5 180 227 351 444 16.3 19.8 14.2 19.1 15.8 20.0 13.4 17.4 14.8 19.2 5.9 7.8
  1. A local-search algorithm allowed us to compute the minima and maxima of each AIO coefficient for the two treatments (Ctrl), (CN) (in mmol/h/half udder of Carbon). These tables allow discriminating the response of the mammary gland to the two treatments without requiring selection of a flux distribution for reactions in the metabolic network. (CN) treatment (protein intake by food) is characterized by a lower proportion of glucose which is oxidized in CO2 than in (Ctrl).
  2. (1)Amino acid input corresponded to positive balances between amino acid net uptake and amino acid and utilization in milk protein (i.e. peptide output).
  3. (2)Amino acid Output corresponded to negative balance between, amino acid net uptake and utilization in milk protein (i.e. peptide output).