Figure 4

TGRL lipolysis treatment network of differentially expressed genes. Edges denote regulatory interactions (TF-DNA binding), yellow are transcription factor (TF) genes and red nodes are differentially regulated targets. Edge weight corresponds to the Pearson correlation coefficient ρ of the expression profiles in connected nodes and the value of the edge (see Additional file 1: Table S1) denotes how statistically significant the interaction is (in all cases p-value < 10^-2). The resulting network has 151 TFs, 272 target genes (X and Y up- and down-regulated, respectively), 236 inhibitory interaction (ρ < -0.25), 265 activatory interactions (ρ > 0.25).