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Table 1 Top 20 differentially expressed (DE) genes (consensus over three methods); Numbers denote the fold-change (FC) between the TGRL + LpL condition and the control (media-only)

From: A systems biology analysis of brain microvascular endothelial cell lipotoxicity

GENE SYMBOL

GENE NAME

iPPLR FC

BGX FC

PPLR FC

p-values

ATF3

Activating transcription factor 3

1,86

2,67

3,06

10-14

BHLHE40

Basic helix-loop-helix family, member e40

0,35

0,23

0,32

10-9

PRNP

Prion protein

1,47

3,09

3,89

10-8

CSGALNACT2

Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1,48

3,90

4,36

10-8

ADD3

Adducin 3 (gamma)

1,61

4,29

4,52

10-7

MAD2L1

MAD2 mitotic arrest deficient-like 1 (yeast)

1,07

3,49

3,31

10-7

ADAM9

ADAM metallopeptidase domain 9

1,22

3,19

3,38

10-7

ZNF217

Zinc finger protein 217

1,83

6,04

4,94

10-7

DDIT3

DNA-damage-inducible transcript 3

1,11

2,50

2,83

10-6

STK39

Serine threonine kinase 39

1,13

2,94

3,81

10-6

LIMS1

LIM and senescent cell antigen-like domains 1

1,14

3,03

3,10

10-6

MMRN1

Multimerin 1

1,62

2,95

3,34

10-5

CSGALNACT2

Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1,06

3,99

3,63

10-5

PAIP1

Poly(A) binding protein interacting protein 1

1,04

2,34

2,80

10-5

HDGFRP3

Hepatoma-derived growth factor, related protein 3

1,05

2,26

2,84

10-5

HES1

Hairy and enhancer of split 1, (Drosophila)

0,56

0,34

0,42

10-5

FRMD4B

FERM domain containing 4B

1,13

2,80

2,92

10-5

DUSP6

Dual specificity phosphatase 6

1,08

3,03

2,71

10-4

PRKAR1A

Protein kinase, cAMP-dependent, regulatory, type I, alpha

1,12

2,69

2,73

10-4

TTC37

Tetratricopeptide repeat domain 37

1,13

2,72

2,48

10-4