Skip to main content

Table 1 Top 20 differentially expressed (DE) genes (consensus over three methods); Numbers denote the fold-change (FC) between the TGRL + LpL condition and the control (media-only)

From: A systems biology analysis of brain microvascular endothelial cell lipotoxicity

GENE SYMBOL GENE NAME iPPLR FC BGX FC PPLR FC p-values
ATF3 Activating transcription factor 3 1,86 2,67 3,06 10-14
BHLHE40 Basic helix-loop-helix family, member e40 0,35 0,23 0,32 10-9
PRNP Prion protein 1,47 3,09 3,89 10-8
CSGALNACT2 Chondroitin sulfate N-acetylgalactosaminyltransferase 2 1,48 3,90 4,36 10-8
ADD3 Adducin 3 (gamma) 1,61 4,29 4,52 10-7
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 1,07 3,49 3,31 10-7
ADAM9 ADAM metallopeptidase domain 9 1,22 3,19 3,38 10-7
ZNF217 Zinc finger protein 217 1,83 6,04 4,94 10-7
DDIT3 DNA-damage-inducible transcript 3 1,11 2,50 2,83 10-6
STK39 Serine threonine kinase 39 1,13 2,94 3,81 10-6
LIMS1 LIM and senescent cell antigen-like domains 1 1,14 3,03 3,10 10-6
MMRN1 Multimerin 1 1,62 2,95 3,34 10-5
CSGALNACT2 Chondroitin sulfate N-acetylgalactosaminyltransferase 2 1,06 3,99 3,63 10-5
PAIP1 Poly(A) binding protein interacting protein 1 1,04 2,34 2,80 10-5
HDGFRP3 Hepatoma-derived growth factor, related protein 3 1,05 2,26 2,84 10-5
HES1 Hairy and enhancer of split 1, (Drosophila) 0,56 0,34 0,42 10-5
FRMD4B FERM domain containing 4B 1,13 2,80 2,92 10-5
DUSP6 Dual specificity phosphatase 6 1,08 3,03 2,71 10-4
PRKAR1A Protein kinase, cAMP-dependent, regulatory, type I, alpha 1,12 2,69 2,73 10-4
TTC37 Tetratricopeptide repeat domain 37 1,13 2,72 2,48 10-4