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Table 2 Predicted top ten protein complexes of breast cancer.

From: Prioritizing protein complexes implicated in human diseases by network optimization

Complex Name Entrez ID Gene Symbol Functional Characterization
RAF1-RAS complex, EGF induced 3265, 3845, 4893, 5894 HRAS, KRAS, NRAS, RAF1 Enzyme mediated signal transduction
RSmad complex 4087, 4088, 4089, 6597, 6599, 6601, 51592, 8202, 1387, 57492 SMAD2, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, TRIM33, NCOA3, CREBBP, ARID1B Transcriptional control; TGF-beta-receptor signalling pathway
Polycysting-1 multiprotein complex 87, 9564, 999, 1499, 3728, 5310, 5747, 5829, 6714, 7094, 7414 ACTN1, BRAR1, CDH1, CTNNB1, JUP, PKD1, PTK2, PXN, SRC, TLN1, VCL Cell adhesion; epithelium
BASC complex (BRCA1-associated genome surveillance complex) 5981, 5982, 5984, 4292, 4436, 2956, 673, 641, 472, 4361, 4683, 10111 RFC1, RFC2, RFC4, MLH1, MSH2, MSH6, BRCA1, BLM, ATM, MRE11A, NBN, RAD50 DNA repair; DNA damage response
MSH2/6-BLM-p53-RAD51 complex 7157, 4436, 2956, 5888, 641 TP53, MSH2, MSH6, RAD51, BLM DNA repair; DNA damage response
Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex 999, 1499, 2319, 5310 CDH1, CTNNB1, FLOT2, PKD1 Lipid binding; intercellular junction (gap junction/adherens junction); epithelium
SMAD3-SMAD4-cJun-cFos complex 2353, 4088, 4089, 3725 FOS, SMAD3, SMAD4, JUN Transcription activation; DNA binding; TGF-beta-receptor signalling pathway
SMAD3/4-E2F4/5-p107-DP1 complex 1874, 1875, 5933, 4088, 4089, 7027 E2F4, E2F5, RBL1, SMAD3, SMAD4, TFDP1 Transcription repression; DNA binding TGF-beta-receptor signalling pathway
Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex 8312, 1499, 2932, 5525 AXIN1, CTNNB1, GSK3B, PPP2R5A Wnt signalling pathway
PBAF complex (SWI/SNF complex) 6597, 6598, 6599, 6601, 6602, 6605, 60, 71, 86, 51412, 196528, 55193 SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTB, ACTG1, ACTL6A, ACTL6B, ARID2, PBRM1 DNA conformation modification; transcription activation; DNA binding; hormone mediated signal transduction; ligand-dependent nuclear receptors; organization of chromosome structure