Table 2 Predicted top ten protein complexes of breast cancer.

RAF1-RAS complex, EGF induced

3265, 3845, 4893, 5894

HRAS, KRAS, NRAS, RAF1

Enzyme mediated signal transduction

RSmad complex

4087, 4088, 4089, 6597, 6599, 6601, 51592, 8202, 1387, 57492

SMAD2, SMAD3, SMAD4, SMARCA4, SMARCC1, SMARCC2, TRIM33, NCOA3, CREBBP, ARID1B

Transcriptional control; TGF-beta-receptor signalling pathway

Polycysting-1 multiprotein complex

87, 9564, 999, 1499, 3728, 5310, 5747, 5829, 6714, 7094, 7414

ACTN1, BRAR1, CDH1, CTNNB1, JUP, PKD1, PTK2, PXN, SRC, TLN1, VCL

Cell adhesion; epithelium

BASC complex (BRCA1-associated genome surveillance complex)

5981, 5982, 5984, 4292, 4436, 2956, 673, 641, 472, 4361, 4683, 10111

RFC1, RFC2, RFC4, MLH1, MSH2, MSH6, BRCA1, BLM, ATM, MRE11A, NBN, RAD50

DNA repair; DNA damage response

MSH2/6-BLM-p53-RAD51 complex

7157, 4436, 2956, 5888, 641

TP53, MSH2, MSH6, RAD51, BLM

DNA repair; DNA damage response

Polycystin-1-E-cadherin-beta-catenin-Flotillin-2 complex

999, 1499, 2319, 5310

CDH1, CTNNB1, FLOT2, PKD1

Lipid binding; intercellular junction (gap junction/adherens junction); epithelium

SMAD3-SMAD4-cJun-cFos complex

2353, 4088, 4089, 3725

FOS, SMAD3, SMAD4, JUN

Transcription activation; DNA binding; TGF-beta-receptor signalling pathway

SMAD3/4-E2F4/5-p107-DP1 complex

1874, 1875, 5933, 4088, 4089, 7027

E2F4, E2F5, RBL1, SMAD3, SMAD4, TFDP1

Transcription repression; DNA binding TGF-beta-receptor signalling pathway

Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex

8312, 1499, 2932, 5525

AXIN1, CTNNB1, GSK3B, PPP2R5A

Wnt signalling pathway

PBAF complex (SWI/SNF complex)

6597, 6598, 6599, 6601, 6602, 6605, 60, 71, 86, 51412, 196528, 55193

SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTB, ACTG1, ACTL6A, ACTL6B, ARID2, PBRM1

DNA conformation modification; transcription activation; DNA binding; hormone mediated signal transduction; ligand-dependent nuclear receptors; organization of chromosome structure