Two examples of the interplay modules of DNA methylation and chromatin modifications. (A) and (B) show the two examples of the cross-talk modules of DNA methylation and chromatin modifications in T2D. The blue and purple nodes represent the TMSN and TCSN genes, respectively. The yellow nodes represent the T2D-related differentially methylated genes, and the light red nodes represent the overlapping genes of the two module groups. The red and green lines represent the positive and negative correlations of the DNA methylation patterns between the two genes, respectively. And the grey dashed lines represent the significant chromatin modification patterns between the two linked genes.