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Figure 3 | BMC Systems Biology

Figure 3

From: Mathematical modeling of GATA-switching for regulating the differentiation of hematopoietic stem cell

Figure 3

Genetic switching of the deterministic GATA-PU.1 regulatory network. (A, B, C) A successful switching leading to high expression level of GATA-1. The mechanism of GATA-switching was realized by a large synthesis rate (μ = 1) in (10). (D, E, F) A successful switching leading to high expression level of gene PU.1 if GATA-1 was knocked down by blocking the expression of GATA-1 (μ = 0). (G, H, I) An unsuccessful switching using an intermediate synthesis rate (μ = 0.32). Parameters of the model are: (a1, a2, a3, a4, a5, a6, a7) = (731.7409, 856.1247, 1, 1.6, 398.9719, 44.8982, 53.0), (b1, b2 ,b3, b4, b5, b6) = (18470.6419, 1, 37.3615, 942.1939, 55.0375, 53.0), (c1, c2, c3, c4, c5, c6, c7) = (12391.1968, 1, 710.4490, 522.4385, 170.0, 1700.0, 1700.0), and (k1, k2 , k3) = (0.6931, 1.3863, 0.2888).

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