Category | Continuous Variable for Quantitative Analysis | Discrete Variable | Bins | Characteristics | Differentially expressed genes at FDR < 0.05 |
---|---|---|---|---|---|
Chronic Bronchitis | Not applicable | Cough with Phlegm for at least 3 mos/yr for at least 2 years | low extreme (Q1 = 64) | neither chronic cough nor chronic phlegm | 0 |
high extreme (Q4 = 46) | both chronic cough and chronic phlegm | ||||
History of Exacerbations | Number of exacerbations per year | 2 or more per year and less than 2 per year | low extreme (Q1 = 26) | 0 - Never | 0 |
high extreme (Q4 = 17) | 3 - Always | ||||
Body Mass Index (Kg/m2) | BMI | BMI < 21, 21-30, > 30 | low extreme (Q1 = 18) | BMI < 21 | 0 |
high extreme (Q4 = 35) | BMI > 30 | ||||
Airflow Limitation severity | FEV1 (% predicted) | GOLD Stage | low extreme (Q1 = 69) | < 2-GOLD stage | 6,049 |
high extreme (Q4 = 13) | >4 GOLD stage | ||||
6 Minute Walk Distance | Quantitative 6MWD | < 350 meters and > 350 meters | low extreme (Q1 = 38) | >350 meters | 0 |
high extreme (Q4 = 101) | >350 meters | ||||
Radiologist Emphysema | Emphysema severity category: | low extreme (Q1 = 40) | 0-1.5 -No emphysema | 0 | |
assessment | Not affected (N): 0 | Yes/No/Uncertain | high extreme (Q4 = 45) | 4-5 - severe | |
Trivial (T): 1 | |||||
Mild (M) 5-25%: 2 | |||||
Moderate (O) 25-50%: 3 | |||||
Severe (S) 50-75%: 4 | |||||
Very Severe (V) > 75%: 5 | |||||
Densitometric Emphysema | Emphysema at -950 HU | Emphysema >10% (Yes/No) | low extreme (Q1 = 37) | Emphysema >10% = No | 0 |
high extreme (Q4 = 95) | Emphysema >10% = yes | ||||
CT Airway Disease | Pi10 (Square root of wall area of 10 mm internal perimeter airways) | GOLD Stages 2-4 with Emphysema < 5% (Yes) or > 5% (No) | low extreme (Q1 = 63) | Trivial (< %5) | 0 |
high extreme (Q4 = 33) | Severe (50-75%, very severe (>75%)) |