Table 4 The 10 most strongly enriched pathways in the set of genes common among all four groups described in table 3, as well as in the individual gene sets of each group.
Top ten pathways among Common Genes | |||
|---|---|---|---|
pathway | p-value | overlap | all pathway genes |
REACTOME_GENE_EXPRESSION | 1.22E-35 | 235 | 425 |
REACTO ME_DIABETES_PATHWAYS | 1.91E-33 | 214 | 383 |
REACTOME_METABOLISM_OF_PROTEINS | 9.48E-28 | 134 | 215 |
REACTOME_CELL_CYCLE_MITOTIC | 7.34E-25 | 167 | 306 |
REACTOME_GLUCOSE_REGULATION_OF_ INSULIN_SECRETION | 1.24E-23 | 104 | 161 |
KEGG_HUNTINGTONS_DISEASE | 3.16E-23 | 114 | 185 |
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM | 1.09E-21 | 130 | 229 |
REACTOME_ELECTRON_TRANSPORT_CHAIN | 1.11E-21 | 60 | 75 |
REACTOME_RNA_POLYMERASE_I_III_AND_MITOCHONDRIAL_TRANSCR.PT.ON | 2.72E-21 | 82 | 120 |
REACTOME_INFLUENZA_LIFE_CYCLE | 1.11E-20 | 89 | 137 |
Top ten pathways among Group 1 Genes | |||
pathway | p -value | overlap | all pathway genes |
REACTOME_INORGANIC_CATION_ANION_SLC_TRANSPORTERS | 0.00133586 | 7 | 94 |
KEGG_SMALL_CELL_LUNG_CANCER | 0.00359651 | 6 | 84 |
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | 0.00723812 | 6 | 97 |
KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG | 0.00921957 | 3 | 25 |
REACTOME_AM.NO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | 0.00984371 | 4 | 48 |
REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT | 0.01009928 | 8 | 169 |
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY | 0.01020969 | 5 | 75 |
KEGG_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTO_AND_NEOLACTO_SERIES | 0.0102887 | 3 | 26 |
REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | 0.01133769 | 4 | 50 |
REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC:ORIGIN_COMPLEX | 0.01516009 | 2 | 11 |
Top ten pathways among Group II Genes | |||
pathway | p -value | overlap | all pathway genes |
REACTOME_REG ULATION_OF_GENE_EXPRESSIO N_IN_B ETA_CELLS | 0.00552 | 5 | 101 |
REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | 0.00637 | 2 | 11 |
REACTOME_GTP_HYDROLYSIS_AND_JOINING_OF_THE_60S_RIBOSOMAL_SUBUNIT | 0.00675 | 5 | 106 |
REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | 0.00759 | 2 | 12 |
REACTOME_REGULATION_OF_BETA_CELLDEVELOPMENT | 0.00911 | 5 | 114 |
REACTOME_TRANSLATION | 0.01121 | 5 | 120 |
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES | 0.01148 | 7 | 218 |
REACTOME_IRS_RELATED_EVENTS | 0.01182 | 4 | 79 |
REACTOME_INFLUENZA_LIFE_CYCLE | 0.01889 | 5 | 137 |
REACTOME_DEADENYLATION_OF_MRNA | 0.02469 | 2 | 22 |
Top ten pathways among Group III Genes | |||
pathway | p -value | overlap | all pathway genes |
REACTOME_DOWN_STREAM_SIGNAL_TRANSDUCTION | 0.00302075 | 5 | 35 |
REACTOME_GAB1_SIGNALOSOME | 0.00324484 | 3 | 11 |
REACTOME_SIGNALING_IN_IMMUNE_SYSTEM | 0.00470548 | 20 | 366 |
REACTOME_MITOTIC_PROMETAPHASE | 0.00489389 | 8 | 92 |
REACTOME_INNATE_IMMUNITY_SIGNALING | 0.00584887 | 10 | 136 |
REACTOME_SIGNALLING_TO_RAS | 0.0060289 | 4 | 26 |
REACTOME_FORMATION_OF_PLATELET_ PLUG | 0.00753191 | 12 | 186 |
REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS | 0.00821656 | 3 | 15 |
REACTOME_MYOGENESSIS | 0.00895252 | 4 | 29 |
REACTOME_HEMOSTASIS | 0.01301061 | 15 | 274 |
Top ten pathways among Group IV Genes | |||
pathway | p -value | overlap | all pathway genes |
REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | 0.00059 | 12 | 173 |
REACTOME_GAP_JUNCTION_ASSEMBLY | 0.00076 | 4 | 19 |
KEGG_CHEMOKINE_SIGNALING_PATHWAY | 0.00133 | 12 | 190 |
REACTOME_GAP_JUNCTION_TRAFICKING | 0.00340 | 4 | 28 |
REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | 0.00787 | 5 | 55 |
REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS | 0.00936 | 4 | 37 |
REACTOME_SIGNALING_IN_IMMUNE_SYSTEM | 0.00943 | 16 | 366 |
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY | 0.01126 | 7 | 108 |
REACTOME_CELL_CYCLE_CHECKPOINTS | 0.01237 | 7 | 110 |
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY | 0.01263 | 8 | 137 |