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Figure 7 | BMC Systems Biology

Figure 7

From: Complex-based analysis of dysregulated cellular processes in cancer

Figure 7

Differential PPI network constructed for normal vs PDAC. (a) Largest component of the network composed of 519 interactions among 558 proteins, out of which 439 (or 84.5%) interactions showed a decrease in co-expression from normal to PDAC (red interactions indicate increase from normal to PDAC while green indicate decrease); (b) several genes are silenced by ubiquitination and sumoylation in PDAC; (c) several known drug targets are centered around interactions showing increase in co-expression.

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