Skip to main content

Table 2 Top enriched terms in KEGG pathways and Biological Process in disrupted complexes in pancreatic (normal vs PDAC) and breast (BRCA1 vs BRCA2) tumours (using DAVID [32]).

From: Complex-based analysis of dysregulated cellular processes in cancer

Category Pancreatic Breast
  Annotation Enrichment Annotation Enrichment
   Genes(%) p-value   Genes(%) p-value
KEGG pathways Cell cycle 4.6 3.5 × 10−13 Cell cycle 3.2 2.7 × 10−7
  Pathways in cancer 6.2 5.8 × 10−7 Pathways in cancer 5.8 2.9 × 10−7
  RIG-I-like receptor signalling 2.2 1.1 × 10−5 Nucleotide excision repair 1.6 1.5 × 10−5
  Neurotrophin signalling 3.0 1.7 × 10−5 DNA replication 1.4 6.4 × 10−5
  Nucleotide excision repair 1.7 1.9 × 10−5 Adipocytokine signalling 1.8 7.5 × 10−7
  Pancreatic cancer 2.1 5.7 × 10−5 Apoptosis 2.1 1.2 × 10−4
  Adipocytokine signalling 2.0 9.7 × 10−5 Neurotrophin signaling 2.3 9.5 × 10−4
  Regulation of autophagy 1.3 3.4 × 10−4 Homologous recombination 1.0 1.6 × 10−3
  Mismatch repair 1.0 5.2 × 10−4 Insulin signaling 2.2 6.0 × 10−3
  Wnt signalling 2.8 2.2 × 10−3 Mismatch repair 0.9 2.8 × 10−3
Biological Process Cell cycle 17.3 1.6 × 10−35 Chromosome organization 14.3 1.5 × 10−43
  Chromosome organization 13.0 6.2 × 10−33 Chromatin organization 12.2 1.3 × 10−40
  RNA splicing 9.2 2.5 × 10−28 Cell cycle 14.5 7.0 × 10−25
  Chromatin modication 8.9 1.0 × 10−27 Regulation of transcription 31.6 1.1 × 10−24
  1. 700 genes tested in pancreatic and 550 genes tested in breast