Table 2 Top enriched terms in KEGG pathways and Biological Process in disrupted complexes in pancreatic (normal vs PDAC) and breast (BRCA1 vs BRCA2) tumours (using DAVID [32]).
From: Complex-based analysis of dysregulated cellular processes in cancer
Category | Pancreatic | Breast | ||||
|---|---|---|---|---|---|---|
Annotation | Enrichment | Annotation | Enrichment | |||
Genes(%) | p-value | Genes(%) | p-value | |||
KEGG pathways | Cell cycle | 4.6 | 3.5 × 10−13 | Cell cycle | 3.2 | 2.7 × 10−7 |
Pathways in cancer | 6.2 | 5.8 × 10−7 | Pathways in cancer | 5.8 | 2.9 × 10−7 | |
RIG-I-like receptor signalling | 2.2 | 1.1 × 10−5 | Nucleotide excision repair | 1.6 | 1.5 × 10−5 | |
Neurotrophin signalling | 3.0 | 1.7 × 10−5 | DNA replication | 1.4 | 6.4 × 10−5 | |
Nucleotide excision repair | 1.7 | 1.9 × 10−5 | Adipocytokine signalling | 1.8 | 7.5 × 10−7 | |
Pancreatic cancer | 2.1 | 5.7 × 10−5 | Apoptosis | 2.1 | 1.2 × 10−4 | |
Adipocytokine signalling | 2.0 | 9.7 × 10−5 | Neurotrophin signaling | 2.3 | 9.5 × 10−4 | |
Regulation of autophagy | 1.3 | 3.4 × 10−4 | Homologous recombination | 1.0 | 1.6 × 10−3 | |
Mismatch repair | 1.0 | 5.2 × 10−4 | Insulin signaling | 2.2 | 6.0 × 10−3 | |
Wnt signalling | 2.8 | 2.2 × 10−3 | Mismatch repair | 0.9 | 2.8 × 10−3 | |
Biological Process | Cell cycle | 17.3 | 1.6 × 10−35 | Chromosome organization | 14.3 | 1.5 × 10−43 |
Chromosome organization | 13.0 | 6.2 × 10−33 | Chromatin organization | 12.2 | 1.3 × 10−40 | |
RNA splicing | 9.2 | 2.5 × 10−28 | Cell cycle | 14.5 | 7.0 × 10−25 | |
Chromatin modication | 8.9 | 1.0 × 10−27 | Regulation of transcription | 31.6 | 1.1 × 10−24 | |