Skip to main content

Table 2 The performance of eleven scoring methods in predicting essential proteins, evaluated by the precision of essential proteins in the top ranked list.

From: cytoHubba: identifying hub objects and sub-networks from complex interactome

Top   10 20 30 40 50 60 70 80 90 100
Local-based Method            
  MCC 0.90 0.90 0.87 0.82 0.76 0.73 0.71 0.69 0.70 0.71
  DMNC 0.80 0.80 0.73 0.68 0.64 0.58 0.54 0.53 0.56 0.54
  MNC 0.60 0.50 0.50 0.47 0.48 0.52 0.53 0.54 0.51 0.50
  Degree 0.70 0.55 0.47 0.42 0.46 0.47 0.49 0.47 0.46 0.44
Global-based Method            
  EPC 0.50 0.50 0.47 0.45 0.48 0.45 0.43 0.42 0.41 0.39
  BottleNeck 0.60 0.60 0.43 0.47 0.44 0.42 0.44 0.44 0.43 0.43
  EcCentricity 0.30 0.45 0.40 0.45 0.44 0.47 0.44 0.41 0.37 0.39
  Closeness 0.50 0.45 0.47 0.50 0.50 0.45 0.46 0.47 0.48 0.48
  Radiality 0.50 0.35 0.43 0.50 0.48 0.43 0.47 0.47 0.49 0.48
  Betweenness 0.60 0.55 0.50 0.50 0.46 0.45 0.46 0.47 0.46 0.43
  Stress 0.60 0.55 0.43 0.47 0.46 0.48 0.49 0.45 0.42 0.43