Figure 1
From: Computational analysis of the roles of ER-Golgi network in the cell cycle
ER stress-induced and Golgi-related signaling pathways in the cell cycle. The proposed network includes the input nodes (ATF6, PERK, IRE1) on the ER and S1P/S2P on the Golgi due to ER stress, and 3 output nodes (cell's fate: Cancer, Apoptosis, Alzheimer). The symbol → denotes activation, while denotes inhibition, except ATF6 → S1/2P → ATF6f which represents that, ATF6 enters the Golgi and it is processed by S1/2P, leading to the final product ATF6f.