Simplified sketch plot of the epigenetic profiles and experimental results for RhoBAD. The epigenetic profiles suggest that the predicted CRM RhoBAD is of high confidence and acts as an enhancer/silencer for the transcription of rhomboid. From experimental literature evidence, we know that RhoBAD indeed acts as an enhancer when bound with the Exd/Hth/Abd-A protein complex and acts as a silencer when Sens binds to it. (a) Silencer markers (H3K23ac, H3K27me3). (b) Enhancer markers (H3K4me, H3K18ac).