Table 1 The 27 predicted cooperative TF pairs

1

Reb1

YDR026C

[3]

--

--

2

Fkh2

Fkh1

[1],[2],[3],[4],[7],[8],[38]

Y

mitotic cell cycle and cell cycle control; budding, cell polarity and filament formation

3

Tye7

Cbf1

[3]

Y

metabolism

4

Dig1

Ste12

[3],[7],[20]

Y

protein folding; pheromone response, mating-type determination, sex-specific proteins; budding, cell polarity and filament formation

5

Pdr3

Pdr1

---

Y

DNA binding; chemical agent resistance; detoxification

6

Swi6

Mbp1

[2],[3],[4],[5],[7],[20],[38]

Y

DNA synthesis and replication; mitotic cell cycle and cell cycle control; protein with binding function or co-factor requirement (structural or catalytic)

7

Swi6

Swi4

[2],[3],[4],[5],[7],[9],[20],[38]

Y

G1/S transition of mitotic cell cycle

8

Dal80

Gln3

---

Y

regulation of nitrogen metabolism

9

Gln3

Gat1

[3]

Y

regulation of nitrogen metabolism

10

Dal80

Gat1

---

--

regulation of nitrogen metabolism

11

Pho4

Cbf1

---

Y

metabolism; DNA binding

12

Pho4

Tye7

---

--

metabolism

13

Hap3

Hap2

[20]

Y

regulation of C-compound and carbohydrate metabolism

14

Gal80

Gal4

---

Y

regulation of C-compound and carbohydrate metabolism

15

Met31

Met32

[3]

Y

metabolism of methionine; metabolism of cysteine; regulation of amino acid metabolism; regulation of nitrogen, sulfur and selenium metabolism; DNA binding

16

Msn4

Msn2

[3]

Y

DNA binding; stress response

17

Rap1

Fhl1

[3],[8],[20]

Y

---

18

Tec1

Ste12

[3]

Y

budding, cell polarity and filament formation

19

Swi6

Stb1

[3],[7]

Y

G1/S transition of mitotic cell cycle

20

Hap2

Hap5

[8]

Y

regulation of C-compound and carbohydrate metabolism

21

Nrg1

Nrg2

---

Y

protein with binding function or co-factor requirement (structural or catalytic); budding, cell polarity and filament formation

22

Hap3

Hap5

[8],[20]

Y

regulation of C-compound and carbohydrate metabolism

23

Swi4

Stb1

[3],[4],[7]

Y

G1/S transition of mitotic cell cycle

24

Swi5

Ace2

[2],[3],[4],[7],[9]

Y

G1 phase of mitotic cell cycle

25

Sok2

Phd1

[3]

Y

budding, cell polarity and filament formation

26

Hap5

Hap4

---

Y

regulation of C-compound and carbohydrate metabolism

27

Mbp1

Swi4

[1],[2],[3],[6],[7],[9]

Y

mitotic cell cycle and cell cycle control