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Figure 17 | BMC Systems Biology

Figure 17

From: Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection

Figure 17

The sub-network for the iron host-pathogen interspecies interaction network in the damage stage. There were 294 interspecies interactions between C. albicans and zebrafish in the iron host-pathogen interspecies interaction network in the damage stage. There were nine iron-related virulence proteins identified as significantly interactive in C. albicans (pink triangles) and six iron-related immune proteins in zebrafish (pink circles). The main functional modules for C. albicans in the damage stage were identified to be pathogenesis and virulence (ph32, hem3, hap43), metal ion transport (ftr2, fre10), hyphal formation (tpk2, cph1), and filamentous growth (efg1, tup1), while the main functional modules for zebrafish were identified to be the immune response (hamp1, jmjd6) and hematopoiesis-related processes (slc40a1, alas2, tfr1a, hpx).

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