Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection

Table 1 Functional protein pool list.

Protein pool	Proteins symbol
C. albicans iron-related virulence proteins	asc1, bgl2, cat1, hem3, rbt4, rfg1, ppt1, ftr2, nag3, phr2,
	yhb1, bud2, erg3, gcs1, int1, ddr48, fre10, hap43, hmx1, sap10,
	sit1, ftr1, ccc2, cph1, cyr1, dfg16, efg1, hog1, mnn2, rim101,
	snf7, sod1, tup1, vps28, gcn4, sod2, als3, ssn6, tpk2, tpk1,
	mig1
Zebrafish iron-related immune proteins	alas2, atp6v1h, atp7a, ba2, bcl2, calrl2, cyba,
	cybb, ercc2, fech, flvcr1, glrx5, hamp1, hif1ab,
	hmox1, hpx, jak2a, jak2b, jmjd6, mb, ncf1,
	ndfip1, nos2a, nos2b, rsad2, slc11a2, slc25a37, slc40a1,
	sod1, sod2, src, tfr1a
C. albicans glucose-related virulence proteins	cdc19, cdc24, cek1, tps1, gpr1, tps2, spt3, snf1, gpa2, rim8,
	cst20, ino1, fba1, hsl1, cnh1, cdc42, gsc1, fbp1, asc1, itr1,
	rim20, tpk2, hgt4, hxk1, cdc14, orf19.6739, orf19.7670
Zebrafish glucose-related immune proteins	angpt2, arg2, bad, bpgm, cyba, dbh, edn1,
	egr1, fgf21, foxo3a, gpia, gpib, hdac4, hif1ab,
	hprt1, ins, lrp5, onecut1, onecutl, pgm3, pla2g1b,
	pparg, prkcq, ptenb, rpl11, slc11a2, slc16a3, slc3a2,
	slc7a6, src, thbs1, tnfa, tnfb, yes1

Proteins used to construct iron- and glucose competition interspecies networks are selected from C. albicans and zebrafish based on function annotation with ANOVA-selection. They can be classified into four groups: 1. C. albicans iron-related 2. zebrafish iron-related 3. C. albicans glucose-related and 4. zebrafish glucose-related.

ISSN: 1752-0509