A regulatory similarity measure using the location information of transcription factor binding sites in Saccharomyces cerevisiae

Table 6 Comparison of six regulatory similarities on three applications

RS measure	FES¹	CES²	IES³	Average⁴
This work	1	1	1	1.0
van Helden	2	2	2	2.0
Veerla and Höglund	3	4	3	3.3
Garten et al.	4	3	4	3.7
Park et al.	5	5	5	5.0
Shalgi et al.	6	6	6	6.0

¹The RS measures are ranked in terms of gene co-function (the area under curve (AUC) of Figure 6a). ²The RS measures are ranked in terms of gene co-expression (the AUC of Figure 6b). ³The RS measures are ranked in terms of protein-protein interaction (the AUC of Figure 6c). ⁴The average of the ranks by gene co-function, gene co-expression and protein-protein interactions.

ISSN: 1752-0509