Computational cell fate modelling for discovery of rewiring in apoptotic network for enhanced cancer drug sensitivity

Mishra, Shital K; Bhowmick, Sourav S; Chua, Huey Eng; Zhang, Fan; Zheng, Jie

doi:10.1186/1752-0509-9-S1-S4

Table 2 Differential equations for the basic apoptosis network N₁ (Figure 1)

From: Computational cell fate modelling for discovery of rewiring in apoptotic network for enhanced cancer drug sensitivity

S.N.	Rate of Change	Differential equations
1	$\frac{d}{d t} Casp 6$	- [Casp6]·rc₁₁ + [Casp9]·rc₁₂
2	$\frac{d}{d t} CDK 1$	+[Wee1]·rc₁₃ - [CDK1]·rc₁₄
3	$\frac{d}{d t} Wee 1$	- [Wee1]·rc₁₃
4	$\frac{d}{d t} JNK$	- [JNK]·rc₁₅ + [EGFR]·rc₁₇
5	$\frac{d}{d t} BID$	- [BID]·rc₁₆ - [BID]·rc₂₅
6	$\frac{d}{d t} EGFR$	- [EGFR]·rc₁₇ - [EGFR]·rc₃₂;
7	$\frac{d}{d t} PUMA$	- [PUMA]·rc₁₉ + [p53]·rc₂₇
8	$\frac{d}{d t} Casp 3$	- [Casp3]·rc₁ + [XIAP]·rc₂ + [SMAC]·rc₄ + [Casp8]·rc₇ - [Casp3]·rc₈ +[Casp9]·rc₉ +[Casp6]·rc₁₁ + [MOMP]·rc₃₀
9	$\frac{d}{d t} Casp9$	- [Casp9]·rc₉ - [Casp9]·rc₁₂ + [PUMA]·rc₁₉ - [Casp9]·rc₂₄ + [BCL2]·rc₂₆
10	$\frac{d}{d t} HER2$	- [HER2]·rc₂₀ - [HER2]·rc₃₁
11	$\frac{d}{d t} Casp8$	- [Casp8]·rc₃ + [RIP1]·rc₆ - [Casp8]·rc₇ + [Casp3]·rc₈ + [BID]·rc₂₅ +[EGFR]·rc
12	$\frac{d}{d t} Apop$	+[Casp3]·rc₁
13	$\frac{d}{d t} XIAP$	- [XIAP]·rc₂ + [SMAC]·rc2₁ + [Casp9]·rc₂₄ + [HER2]·rc₃₁
14	$\frac{d}{d t} SMAC$	+[Casp8]·rc₃ - [SMAC]·rc₄ + [BCL2]·rc₅ - [SMAC]·rc₂₁ + [MOMP]·rc₂₉
15	$\frac{d}{d t} BCL2$	- [BCL2]·rc₅ + [p53]·rc₁₀ + [CDK1]·rc₁₄ + [JNK]·rc₁₅ +[BID]·rc₁₆ +[STAT3]·rc₂₂ - [BCL2]·rc₂₆
16	$\frac{d}{d t} RIP1$	- [RIP1]·rc₆ + [TNFR]·rc₂₃
17	$\frac{d}{d t} P53$	- [p53]·rc₁₀ + [AKT]·rc₁₈ - [p53]·rc₂₇
18	$\frac{d}{d t} AKT$	- [AKT]·rc₁₈ + [HER2]·rc₂₀
19	$\frac{d}{d t} STAT3$	- [STAT3]·rc₂₂
20	$\frac{d}{d t} TNFR$	- [TNFR]·rc₂₃
21	$\frac{d}{d t} DAPK 1$	- [DAPK1]·rc₂₈
22	$\frac{d}{d t} MOMP$	+[DAPK1]·rc₂₈ - [MOMP]·rc₂₉ - [MOMP]·rc₃₀

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ISSN: 1752-0509

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