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Table 2 Differential equations for the basic apoptosis network N1 (Figure 1)

From: Computational cell fate modelling for discovery of rewiring in apoptotic network for enhanced cancer drug sensitivity

S.N. Rate of Change Differential equations
1 d d t Casp 6 - [Casp6]·rc11 + [Casp9]·rc12
2 d d t CDK 1 +[Wee1]·rc13 - [CDK1]·rc14
3 d d t Wee 1 - [Wee1]·rc13
4 d d t JNK - [JNK]·rc15 + [EGFR]·rc17
5 d d t BID - [BID]·rc16 - [BID]·rc25
6 d d t EGFR - [EGFR]·rc17 - [EGFR]·rc32;
7 d d t PUMA - [PUMA]·rc19 + [p53]·rc27
8 d d t Casp 3 - [Casp3]·rc1 + [XIAP]·rc2 + [SMAC]·rc4 + [Casp8]·rc7 - [Casp3]·rc8 +[Casp9]·rc9 +[Casp6]·rc11 + [MOMP]·rc30
9 d d t Casp9 - [Casp9]·rc9 - [Casp9]·rc12 + [PUMA]·rc19 - [Casp9]·rc24 + [BCL2]·rc26
10 d d t HER2 - [HER2]·rc20 - [HER2]·rc31
11 d d t Casp8 - [Casp8]·rc3 + [RIP1]·rc6 - [Casp8]·rc7 + [Casp3]·rc8 + [BID]·rc25 +[EGFR]·rc
12 d d t Apop +[Casp3]·rc1
13 d d t XIAP - [XIAP]·rc2 + [SMAC]·rc21 + [Casp9]·rc24 + [HER2]·rc31
14 d d t SMAC +[Casp8]·rc3 - [SMAC]·rc4 + [BCL2]·rc5 - [SMAC]·rc21 + [MOMP]·rc29
15 d d t BCL2 - [BCL2]·rc5 + [p53]·rc10 + [CDK1]·rc14 + [JNK]·rc15 +[BID]·rc16 +[STAT3]·rc22 - [BCL2]·rc26
16 d d t RIP1 - [RIP1]·rc6 + [TNFR]·rc23
17 d d t P53 - [p53]·rc10 + [AKT]·rc18 - [p53]·rc27
18 d d t AKT - [AKT]·rc18 + [HER2]·rc20
19 d d t STAT3 - [STAT3]·rc22
20 d d t TNFR - [TNFR]·rc23
21 d d t DAPK 1 - [DAPK1]·rc28
22 d d t MOMP +[DAPK1]·rc28 - [MOMP]·rc29 - [MOMP]·rc30