Figure 10
From: Single-molecule modeling of mRNA degradation by miRNA: Lessons from data
Network of the "Control(+)" data. Biochemical network able to fit the data when all three factors miRISC, NOT1 and PAN3 are expressed. After fixing the rates µ, λ and ν from the fitting of the negative decay pattern in Figure 4, we use this network in order to model the decay pattern when all three factors are expressed. The transition from the central state (green) to the state with the mRNA bound to the preformed complex miRISC + NOT1 + PAN3 is ruled by the transition rate λRNP. The downwards transition, ruled by the rate µRNP includes several steps that cannot be specified from these data.