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Figure 8 | BMC Systems Biology

Figure 8

From: Single-molecule modeling of mRNA degradation by miRNA: Lessons from data

Figure 8

Biochemical network fitting the data when PAN3 has been knocked down. After fixing the rates µ, λ and ν from the fitting of the negative decay pattern in Figure 4, we use this network in order to model the decay pattern when miRNA is expressed but PAN3 is knocked down ("PAN3 KD" data). The transition from the central green state to the state with the mRNA bound to the preformed complex miRISC + NOT1 is ruled by the transition rate λRN. The downwards transition, ruled by the rate µRN includes several steps that cannot be specified from these data.

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