Figure 9

Fit of the data PAN3 KD. After fixing the rates µ, λ, ν from the fitting of the negative decay pattern in Figure 4, we use the network in Figure 8 in order to fit the decay pattern when miRNA is expressed but PAN3 is knocked down. The values of the rates are λ_RN = 0.046 min⁻¹ and µ_RN = 0.0461 min⁻¹ with 95% confidence intervals [0.0305, 0.0687] and [0.0319, 0.0602], respectively. These rates indicate that in the absence of PAN3, about 64 % of the mRNA in the experiment are degraded by the action of miRISC.