Analysis of the two-module network with the TetR/Ptet-based NOT gate, when OUTPUT
are affected by constant CV noise with correlation coefficient ρ. A) Variability among the estimated parameters, in terms of CV. B) Maximum percentage difference between estimated and true parameter values. All the results are shown as a function of the correlation coefficient ρ, which is varied from 0 (no correlation) to 1 (maximum correlation). The increase of ρ value simulates an increase in proportion of the extrinsic component of noise over the total noise, which is composed of the intrinsic and extrinsic components.