Modelling the effects of cell-to-cell variability on the output of interconnected gene networks in bacterial populations

Table 2 Estimated parameters for Module 2 as a function of noise model and entity.

Parameter:	α _OUT [RPU]	δ _OUT [RPU]	k _OUT [RPU]	η _OUT [-]
TetR/Ptet (constant CV)	3.00 3.04 3.06 (1%)	0.05 0.04 0.02	0.20 0.23 0.25 (10.5%)	1.96 1.65 1.49 (14.2%)
TetR/Ptet (constant VAR)	2.85 2.87 2.87 (0.4%)	0.04 0.04 0.03	0.27 0.30 0.32 (9.4%)	2.53 2.18 2.18 (0.6%)
LacI/Plac (constant CV)	0.50 0.46 0.43 (6.6%)	0 0.04 0.07	3.20 3.27 3.32 (1.8%)	1.88 1.70 1.60 (8.2%)
LacI-Plac (constant VAR)	0.50 0.50 0.50 (0.2%)	0 0 0	3.22 3.23 3.25 (0.4%)	1.90 1.90 1.89 (0.2%)
A-PA (constant CV)	3.00 3.04 3.06 (1%)	0.05 0.02 0.02	0.20 0.23 0.25 (10.5%)	1.96 1.65 1.49 (14.2%)
A-PA (constant VAR)	2.85 2.87 2.87 (0.4%)	0.21 0.19 0.19	0.27 0.30 0.32 (9.4%)	2.15 2.18 2.18 (0.6%)

Parameters are obtained by fitting population-averaged values of OUTPUT₂ as a function of OUTPUT₁ for different noise models and entity, applied to OUTPUT₁. The three values reported in each cell correspond to CV = 0.15, 0.55, 0.75 (for constant CV models) and to VAR = 0.05, 0.1, 0.15 (for constant VAR models). The CV among the estimated parameters is reported in brackets.

ISSN: 1752-0509