Table 2 Representative P.falciparum proteins that were predicted to be associated with pathogenesis.

DNA replication

PF3D7_0111300

replication factor c protein, putative

Transcription and transcriptional regulation

PF3D7_0923000

DNA-directed RNA polymerase II, putative

PF3D7_1206600

DNA-directed RNA polymerase III subunit, putative

PF3D7_0206600

transcription factor, putative

PF3D7_1451400

transcriptional regulatory protein sir2b (Sir2B)

PF3D7_1342700

transcription activator, putative

Translation

PF3D7_1460700

60S ribosomal protein L27, putative

PF3D7_1421200

40S ribosomal protein S25, putative

PF3D7_1451100

elongation factor 2

PF3D7_0422700

eukaryotic translation initiation factor 4F complex

Protein phosphorylation and signaling

PF3D7_0826700

receptor for activated C kinase homolog, PfRACK

PF3D7_0424500

serine/threonine protein kinase, FIKK family (FIKK4.1)

PF3D7_0623800

protein kinase, putative (TKL4)

Regulation of cell cycle

PF3D7_1428300

proliferation-associated protein 2g4, putative

PF3D7_0619400

cell division cycle protein 48 homologue, putative

Proteolysis

PF3D7_0933600

mitochondrial-processing peptidase subunit beta, putative (MAS1)

PF3D7_0904400

signal peptidase complex subunit 3, putative (SPC3)

PF3D7_1331300

signal peptidase 21 kDa subunit (SP21)

PF3D7_1130400

26S protease subunit regulatory subunit 6a, putative

Heat shock response

PF3D7_0708800

heat shock protein 110 (HSP110c)

PF3D7_1357800

TCP-1/cpn60 chaperonin family, putative

PF3D7_1215300

10 kd chaperonin, putative

PF3D7_0308200

TCP-1/cpn60 chaperonin family, putative

PF3D7_0214000

TCP-1/cpn60 chaperonin family, putative