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Table 4 Protein classification of the potential SCZ drug targets

From: A weighted and integrated drug-target interactome: drug repurposing for schizophrenia as a use case

Protein class Protein Potential SCZ drugs with
clinical trials
Receptor ADRA1A Trazodone  
  CHRM1 Benztropine Desipramine
  DRD1 Pergolide Dopamine
  DRD2 Bromocriptine Pergolide
   Pramipexole Dopamine
   Buspirone Levodopa
  DRD3 Bromocriptine Pergolide
   Pramipexole Dopamine
  DRD4 Pramipexole Levodopa
   Dopamine  
  DRD5 Dopamine  
  HRH1 Betahistine Cinnarizine
   Cyproheptadine Desipramine
   Promethazine Mirtazapine
  HRH2 Famotidine Nizatidine
  HTR1A Naratriptan Buspirone
  HTR1B Naratriptan  
  HTR1D Naratriptan  
  HTR2A Mirtazapine Zotepine
   Trazodone  
  HTR2C Agomelatine Mirtazapine
Transporter SLC6A2 Atomoxetine Desipramine
   Methamphetamine Reboxetine
   Methylphenidate Sibutramine
  SLC6A3 Dexmethylphenidate Methylphenidate
  SLC6A4 Citalopram Fluoxetine
   Fluvoxamine Paroxetine
   Methamphetamine Sertraline
   Sibutramine Trazodone
Transporter; GABRA1 Lorazepam Diazepam
Receptor   Nitrazepam Zolpidem
  GABRG2 Lorazepam Diazepam
  GRIN2B Memantine  
  HTR3A Ondansetron Mirtazapine
(Not available) ADRA2A Dexmedetomidine Clonidine
   Mirtazapine Guanfacine
  ADRA2B Clonidine  
  ADRA2C Dexmedetomidine Clonidine