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Table 5 Potential SCZ drugs identified by using different data sources and threshold

From: A weighted and integrated drug-target interactome: drug repurposing for schizophrenia as a use case

Data source Threshold #Potential SCZ drugs #Drugs in SCZ-CTa #Drugs in MTL-CTb
WinDTome Score_S ≥ 3 264 39 (14.8%) 74 (28.0%)
  Score_S ≥ 2 1,354 76 (5.6%) 102 (7.5%)
  Score_S ≥ 1 37,680 191 (0.5%) 292 (0.8%)
DrugBank   490 45 (9.2%) 87 (17.8%)
KEGG   375 30 (8.0%) 70 (18.7%)
TTD   2,388 27 (1.1%) 62 (2.6%)
MATADOR   374 48 (12.8%) 82 (21.9%)
PDSP   2,001 39 (1.9%) 59 (2.9%)
BindingDB   34,748 41 (0.1%) 98 (0.3%)
STITCH Combined score ≥ 0.7 32,282 100 (0.3%) 241 (0.7%)
  1. aSCZ-CT represents the schizophrenia-relevant clinical trials.
  2. bMTL-CT represents the mental disorders-relevant clinical trials.