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Figure 5 | BMC Systems Biology

Figure 5

From: YAGM: a web tool for mining associated genes in yeast based on diverse biological associations

Figure 5

Comparison of the search results of YAGM, STRING, and GeneMANIA. Using FKS1 as a query gene, we compare the three lists of top ten associated genes obtained from these three tools when all biological associations are used together. It can be seen that nine genes (GAS1, ECM33, SMI1, CCW12, KRE6, PSA1, EXG1, PFK2 and SCW4) are predicted only by YAGM. We then check the biological plausibility of our novel predictions by using the gene description content in SGD database. Seven (the gene names with red colors) of the nine newly predicted associated genes are known to be involved in cell wall process or glucan biosynthesis just like the query gene FKS1, suggesting that YAGM can predict biologically plausible associated genes of a query gene. That is, YAGM can provide alternative candidates of biologically plausible associated genes for biologists to do further experimental investigation.

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