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Figure 2 | BMC Systems Biology

Figure 2

From: Functional redundancy of transcription factors explains why most binding targets of a transcription factor are not affected when the transcription factor is knocked out

Figure 2

Functional redundancy explains the low overlap percentage. The set of TFs with high/low functional redundancy is defined as those TFs whose functional redundancy are among the top/bottom X% of the 173 TFs under study. By using the one-sided two-sample proportion test [28], we find that TFs with high functional redundancy show significantly (p-value << 0.001) lower overlap percentage than do TFs with low functional redundancy, suggesting that functional redundancy may explain why most binding targets of a TF are not affected when the TF is knocked out. Note that our result is robust against different choices (10, 20, 30, 40 or 50) of X and different sources ((a)MIPS [17], (b) GO:BP [16] or (c) GO:MF [16]) of functional annotation terms being used. The red line indicates the overlap percentage (4%) for all 173 TFs under study.

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BMC Systems Biology

ISSN: 1752-0509

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