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Figure 4 | BMC Systems Biology

Figure 4

From: Functional redundancy of transcription factors explains why most binding targets of a transcription factor are not affected when the transcription factor is knocked out

Figure 4

Lacking a TATA box is associated with a gene being insensitive to the knockout of its promoter-binding TFs. By using the one-sided two-sample proportion test [28], we find that TATA box-less genes show significantly (p-value << 0.001) lower overlap percentage compared with TATA box-containing genes, suggesting that lacking a TATA box is associated with a gene being insensitive to the knockout of its promoter-binding TFs. Note that our result is robust against three different criteria ((a), (b), and (c)) for defining TATA box-containing genes being used (see Basehoar et al.'s study [21] for more details). The red line indicates the overlap percentage (4%) for all 4065 genes under study.

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BMC Systems Biology

ISSN: 1752-0509

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