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Figure 12 | BMC Systems Biology

Figure 12

From: Identification of network-based biomarkers of cardioembolic stroke using a systems biology approach with time series data

Figure 12

LRRK2 in neurons in Parkinson's disease which is the fifth scored pathway map in MetaCore enrichment analysis results. Mutation in LRRK2 (R1441C, R1441G, R1441H, Y1699C, I2020T and G2019S) are the most common genetic cause of Parkinson's disease, and LRRK2 stimulates various pathways leading to progression of Parkinson's disease. Ubiquitin was down-regulated in stoke samples at 3, 5, 24 hours and overall stroke samples as compared with control. LRRK2 was up-regulated in overall stroke samples.

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BMC Systems Biology

ISSN: 1752-0509

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