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Figure 2 | BMC Systems Biology

Figure 2

From: Identification of network-based biomarkers of cardioembolic stroke using a systems biology approach with time series data

Figure 2

The constructed differential protein-protein interaction (PPI) networks (PPINs; DPPINs) for 3 time points post-stroke. This shows the DPPINs with edge and node information for 3 time points after a stroke occurred. It is the difference between the stroke PPIN (SPPIN) and normal PPIN (NPPIN). The node size means the stroke relevance value (SRV) of each protein, and the edge width is proportional to the link ability between the 2 proteins. Red and blue edges respectively indicate positive and negative values of d ij in (7). Besides UBC, we see at 3 h that CUL3, ATXN2L, TTN, and NRF2 dominate the network. At 5 h, APP, CUL3, NEDD8, EVAL1, TCO, PAN, and JUP dominate the network. At 24 h, CLU3 and APP dominate the network. We suggest that readers examine these figures together with Table 2. Information of the SRV and PPI are important for you to develop new therapeutic methods for stroke recovery. The figures were created using Cytoscape.

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BMC Systems Biology

ISSN: 1752-0509

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