Figure 5

IPA results at 24 h post-stroke. By the IPA analysis, one can see that the 3 network markers are related to different modules at 3 different time points (3, 5, and 24 h) post-stroke. It is easy to see the evolutionary process of network biomarkers. From the detailed legend in Figure 6, one can see different regulatory mechanisms at these 3 time points of stroke. This abundant information can offer experts various novel strategies to develop stroke therapies or recovery methods. The experts can decide to inhibit or activate key proteins in these networks. And experts can refer to a patient's medical history to decide the therapeutic strategy. We analyzed the stroke relevance value (SRV) results by IPA software, and it gave us more clues to uncover hidden mechanisms of stroke. We consider this inspired pioneering work, and in the future, experts need to design new therapies or recovery strategies for validation.