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Table 4 Pathway analysis and gene set enrichment analysis of 5 proteins at 3 h post-stroke on (1) biological processes, (2) cellular components and (3) molecular functions by NOA.

From: Identification of network-based biomarkers of cardioembolic stroke using a systems biology approach with time series data

GO: term

pvalue

Corrected pvalue

R

T

G

O

Term name

(1) Biological Processes

GO:0042787

0.0033

0.0825

6357

1

21

1

protein ubiquitination involved in ubiquitin-dependent protein catabolic process

GO:0016567

0.0135

0.3382

6357

1

86

1

protein ubiquitination

GO:0032446

0.0171

0.4286

6357

1

109

1

protein modification by small protein conjugation

GO:0070647

0.0215

0.5387

6357

1

137

1

protein modification by small protein conjugation or removal

GO:0019941

0.0272

0.6803

6357

1

173

1

modification-dependent protein catabolic process

GO:0006511

0.0272

0.6803

6357

1

173

1

ubiquitin-dependent protein catabolic process

GO:0051603

0.0289

0.7236

6357

1

184

1

proteolysis involved in cellular protein catabolic process

GO:0043632

0.03

0.7511

6357

1

191

1

modification-dependent macromolecule catabolic process

GO:0006508

0.047

1

6357

1

299

1

proteolysis

(2) Cellular Components

GO:0031463

7.8E-4

0.0110

6357

1

5

1

Cul3-RING ubiquitin ligase complex

GO:0031461

0.0042

0.0594

6357

1

27

1

cullin-RING ubiquitin ligase complex

GO:0000151

0.0099

0.1387

6357

1

63

1

ubiquitin ligase complex

(3) Molecular Functions

GO:0031625

0.0020

0.0224

6357

1

13

1

ubiquitin protein ligase binding

GO:0019899

0.0056

0.0622

6357

1

36

1

enzyme binding

GO:0004842

0.0133

0.1470

6357

1

85

1

ubiquitin-protein ligase activity

GO:0019787

0.0143

0.1574

6357

1

91

1

small conjugating protein ligase activity

GO:0016881

0.0157

0.1730

6357

1

100

1

acid-amino acid ligase activity

GO:0016879

0.0212

0.2336

6357

1

135

1

ligase activity, forming carbon-nitrogen bonds

GO:0016874

0.0309

0.3408

6357

1

197

1

ligase activity

  1. R: number of genes in the reference set. T: number of genes in the test set. G: number of genes annotated by a given term in the reference set. O: number of genes annotated by a given term in the test set.