Table 3 Examples of pathway event errors.
PMID | Sentence | PWTEES | Comment |
|---|---|---|---|
8875985 | ...directed the expression of either the A2a adenosine receptor that constitutively activates the cAMP pathway, or the E7 protein | T: cAMP cascade C: E7 protein ET: Positive regulation | The cause should be A2a adenosine receptor. Wrong assignment of argument. |
23261982 | Dkk-1 inhibited the survival and migration of human PTC cells by regulating Wnt/β-catenin signaling and E-cadherin expression. | T: expression of Wnt/beta-catenin signaling and E-cadherin C: Wnt/beta-catenin signaling pathway ET: Regulation | Cause should be Dkk-1 and event type is inhibition. Wrong assignment of argument and event type. |
21690267 | ...the same patient allele carries both K666E and G691S variants, the latter known to increase downstream RET signaling, | T: RET downstream signaling C: ET: Positive regulation | Cause should be G691S variants. Missed argument |
15059947 | ...the MAPK (ERK1/2) signaling pathway causes serine phosphorylation by MAPK of several nucleoproteins | T:{T:MAPK; Site: serine; ET: Phosphorylation} C: MAPK (ERK1/2) signaling pathway ET: Positive Regulation | In the nested theme event, MAPK should be the cause, not the theme. |
16940797 | ZD 6474 has shown promising activity in preclinical models against RET kinase, and its contemporary inhibition of vascular endothelial growth factor and epidermal growth factor pathways | T: VEGF and EGF pathways C: ET: Negative Regulation | Cause should be ZD6474 (drug). |