Table 4 EVEX and PWTEES differences on example sentences.

Mutated BRAF, generates a constitutive activation of the mitogen-activated protein kinases (MAPK) signaling pathway

N/A

T: Activation of MAPK pathway

C: BRAF

ET: Positive regulation

PLD synergistically functions to activate the STAT3 signaling by interacting directly with the thyroid oncogenic kinase RET/PTC.

T1: PLD

T2: RET/PTC

ET: Binding

T: PLD

C: STAT3 signaling

ET: Positive regulation

CD40 stimulation inhibits cell growth and Fas-mediated apoptosis in a thyroid cancer cell line.

Gene/Protein: CD40, Fas

T: Fas-medicated apoptosis

C: CD40 stimulation

ET: Negative regulation

.. and that integration of the Ras/ERK1/2/ELK-1 and STAT3 pathways was required for up-regulation of the c-fos promoter by FMTC-RET

T: c-fos promoter

C: FMTC-RET

ET: Positive regulation

T: up-regulation of the c-fos promoter by FMTC-RET

C: Ras/ERK1/2/ELK-1 and STAT3 pathways

ET: Positive regulation