TY - JOUR AU - Lavi, Orit AU - Skinner, Jeff AU - Gottesman, Michael M. PY - 2014 DA - 2014/07/29 TI - Network features suggest new hepatocellular carcinoma treatment strategies JO - BMC Systems Biology SP - 88 VL - 8 IS - 1 AB - Resistance to therapy remains a major cause of the failure of cancer treatment. A major challenge in cancer therapy is to design treatment strategies that circumvent the higher-level homeostatic functions of the robust cellular network that occurs in resistant cells. There is a lack of understanding of mechanisms responsible for the development of cancer and the basis of therapy-resistance mechanisms. Cellular signaling networks have an underlying architecture guided by universal principles. A robust system, such as cancer, has the fundamental ability to survive toxic anticancer drug treatments or a stressful environment mainly due to its mechanisms of redundancy. Consequently, inhibition of a single component/pathway would probably not constitute a successful cancer therapy. SN - 1752-0509 UR - https://doi.org/10.1186/s12918-014-0088-0 DO - 10.1186/s12918-014-0088-0 ID - Lavi2014 ER -